Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1189-1192., 2021.
Article
in Chinese
| WPRIM
| ID: wpr-876665
ABSTRACT
The incurable chronic infection caused by hepatitis B virus (HBV) is the major health burden worldwide. Covalently closed circular DNA (cccDNA) exists in the nucleus of infected cells as a stable minichromosome, and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected hepatocytes, the natural process of chronic infection and long-term antiviral therapy will no longer exist. This article introduces the methods targeting cccDNA, such as gene editing and epigenetic modification, so as to achieve the complete cure of HBV infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Hepatology
Year:
2021
Type:
Article
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