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Risk Identification and Evaluation of Clinical Trials of I nnovative Drugs under New Policy Environment / 中国药房
China Pharmacy ; (12): 1153-1157, 2021.
Article in Chinese | WPRIM | ID: wpr-876880
ABSTRACT
OBJECTIVE:To identify and evaluate the risk factors of innovative drug clinical trials ,and to provide references for the development of risk management and control strategies. METHODS :Using the method of literature research ,the risk factors of innovative drug clinical trials were obtained ,classified and sorted out ,and the risk evaluation indicators were initially formed. On this basis ,the questionnaire was designed. By means of interview and questionnaire survey ,54 experts were invited from 4 tertiary hospitals and 1 contract research organization to score. SPSS 24.0 software was used to perform principal component analysis on risk event status data. RESULTS & CONCLUSIONS :The risk evaluation system included 9 first-class indicators such as policy and legal riskclinical trial institution risk and trial scheme design risk ,and 31 second-class indicators such as industrial policylaw and regulation changes ,intellectual property risk . According to the analysis ,the risk factors of innovative drug clinical trials mainly included drug and biological sample management risk ,trial scheme design riskclinical trial institution risksafety report management riskethical review riskpolicy and legal risk ,and subject management risk. Relevant parties in clinical trials need to focus on monitoring various risk factors ,establish dynamic monitoring and control mechanism and implementation guarantee mechanism ,and effectively prevent and control risk ,to promote the smooth implementation of clinical trials.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Evaluation studies / Prognostic study / Risk factors Language: Chinese Journal: China Pharmacy Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Evaluation studies / Prognostic study / Risk factors Language: Chinese Journal: China Pharmacy Year: 2021 Type: Article