Investigation and analysis of HBV infection and related cirrhosis in a certain area / 公共卫生与预防医学

ABSTRACT

Objective To investigate and analyze the incidence of hepatitis B virus (HBV) infection and related cirrhosis in a certain area. Methods A retrospective investigation was performed on 365 patients with HBV infection in a certain area from October 2018 to October 2020. The relevant data of the patients and the incidence of HBV infection-related cirrhosis were analyzed to explore the influencing factors for liver cirrhosis caused by HBV infection. Results The age of patients with HBV infection was mainly 31-50 years old (61.92%), who were mainly males (80.00%). The symptoms included yellow urine (66.30%), loss of appetitte (57.53%) and fatigue (46.85%). There was abnormal increase of aspartate aminotransferase and alanine aminotransferase, and hyperbilirubinemia in patients. 35 patients developed liver failure, of whcih 31 patients survived and were discharged, 3 patients underwent liver transplantation and 1 patient died after discharge. Among the 365 patients, there were 82 cases with HBV-related cirrhosis, mainly aged between 31 and 50 years old (63.41%), who were mainly males (80.00%). The main symptoms included abdominal distension (46.34%), liver palm (39.02%) and jaundice (34.15%), and all were accompanied with abnormal liver function indexes. Of the 365 patients, 35.37% of them were complicated with primary peritonitis, and 25.61% with electrolyte imbalance. In addition, 87.80% of the patients improved and were discharged. The incidence rates of upper gastrointestinal bleeding, hepatic encephalopathy and death were 7.32%, 3.66% and 1.22%, respectively. The results of univariate and multivariate analysis showed that drinking history, HBV-DNA level and exercise were the influencing factors of HBV-related cirrhosis (P<0.05). Conclusion Patients with HBV infection and related cirrhosis are mostly middle-aged men. Drinking history, HBV-DNA level and exercise are important influencing factors for HBV infection progression to cirrhosis.