Effect of Horse Oil on Anti-bacterial, Inflammatory Cytokines, and Type I Collagen Expressions in Human HaCaT Keratinocytes and Fibroblasts / 대한피부과학회지
Korean Journal of Dermatology
;
: 1-6, 2014.
Article
in Korean
| WPRIM
| ID: wpr-87777
ABSTRACT
BACKGROUND:
Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown.OBJECTIVE:
The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil.METHODS:
Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts.RESULTS:
Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts.CONCLUSION:
Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Keratinocytes
/
Up-Regulation
/
Blotting, Western
/
Cytokines
/
Collagen
/
Interleukin-10
/
Collagen Type I
/
Diffusion
/
Real-Time Polymerase Chain Reaction
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2014
Type:
Article
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