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Mechanisms of resistance to immune checkpoint inhibitors and strategies to reverse drug resistance in lung cancer / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2444-2455, 2020.
Article in English | WPRIM | ID: wpr-877859
ABSTRACT
In recent years, the research of immune checkpoint inhibitors has made a great breakthrough in lung cancer treatment. Currently, a variety of immune checkpoint inhibitors have been applied into clinical practice, including antibodies targeting the programmed cell death-1, programmed cell death-ligand 1, and cytotoxic T-lymphocyte antigen 4, and so on. However, not all patients can benefit from the treatment. Abnormal antigen presentation, functional gene mutation, tumor microenvironment, and other factors can lead to primary or secondary resistance. In this paper, we reviewed the molecular mechanism of immune checkpoint inhibitor resistance and various combination strategies to overcome resistance, in order to expand the beneficial population and enable precision medicine.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Drug Resistance / Tumor Microenvironment / B7-H1 Antigen / CTLA-4 Antigen / Immune Checkpoint Inhibitors / Immunotherapy / Lung Neoplasms Limits: Humans Language: English Journal: Chinese Medical Journal Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Drug Resistance / Tumor Microenvironment / B7-H1 Antigen / CTLA-4 Antigen / Immune Checkpoint Inhibitors / Immunotherapy / Lung Neoplasms Limits: Humans Language: English Journal: Chinese Medical Journal Year: 2020 Type: Article