Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2966-2975, 2020.
Article
in English
| WPRIM
| ID: wpr-877923
ABSTRACT
Antimicrobial peptides (AMPs) are small molecules produced by a myriad of cells and play important roles not only in protecting against infections and sustaining skin barrier homeostasis but also in contributing to immune dysregulation under pathological conditions. Recently, increasing evidence has indicated that AMPs, including cathelicidin (LL-37), human β-defensins, S100 proteins, lipocalin 2, and RNase 7, are highly expressed in psoriatic skin lesions. These peptides broadly regulate immunity by interacting with various immune cells and linking innate and adaptive immune responses during the progression of psoriasis. In this review, we summarize the recent findings regarding AMPs in the pathogenesis of psoriasis with a main focus on their immunomodulatory abilities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
Skin Diseases
/
Beta-Defensins
/
Pore Forming Cytotoxic Proteins
/
Adaptive Immunity
/
Immunity, Innate
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2020
Type:
Article
Similar
MEDLINE
...
LILACS
LIS