Asymptomatic cryptococcal antigenemia in HIV-infected patients: a review of recent studies / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2859-2866, 2020.
Article
in English
| WPRIM
| ID: wpr-877942
ABSTRACT
The prevalence of asymptomatic cryptococcal antigenemia (ACA) in human immunodeficiency virus (HIV) infected individuals has been observed to be elevated. The prevalence of ACA ranges from 1.3% to 13%, with different rates of prevalence in various regions of the world. We reviewed studies conducted internationally, and also referred to two established expert consensus guideline documents published in China, and we have concluded that Chinese HIV-infected patients should undergo cryptococcal antigen screening when CD4 T-cell counts fall below 200 cells/μL and that the recommended treatment regimen for these patients follow current World Health Organization guidelines, although it is likely that this recommendation may change in the future. Early screening and optimized preemptive treatment for ACA is likely to help decrease the incidence of cryptococcosis, and is lifesaving. Further studies are warranted to explore issues related to the optimal management of ACA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
HIV Infections
/
China
/
Meningitis, Cryptococcal
/
AIDS-Related Opportunistic Infections
/
CD4 Lymphocyte Count
/
Cryptococcosis
/
Cryptococcus
Type of study:
Practice guideline
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Journal
Year:
2020
Type:
Article
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