Heterogeneity of HIV-1 latent reservoirs / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2867-2873, 2020.
Article
in English
| WPRIM
| ID: wpr-877943
ABSTRACT
Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virus Replication
/
CD4-Positive T-Lymphocytes
/
HIV Infections
/
HIV-1
/
Virus Latency
/
Viral Load
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2020
Type:
Article
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