Resveratrol inhibits hypoxia-induced oxidative stress and proliferation in pulmonary artery smooth muscle cells through the HIF-1α/NOX4/ROS signaling pathway / 生理学报
Acta Physiologica Sinica
;
(6): 551-558, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-878200
ABSTRACT
The purpose of the present study was to determine the effects of resveratrol on hypoxia-induced oxidative stress and proliferation in pulmonary artery smooth muscle cells (PASMCs) and the underlying mechanism. Primary rat PASMCs were isolated and cultured in vitro and pretreated with different concentrations of resveratrol (10, 20, and 40 µmol/L) or the NADPH oxidase (NOX) inhibitor VAS2870 (10 µmol/L) for 0.5 h. The cells were then cultured under normoxia (21% O
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Artery
/
Signal Transduction
/
Cells, Cultured
/
Reactive Oxygen Species
/
Oxidative Stress
/
Myocytes, Smooth Muscle
/
Cell Proliferation
/
NADPH Oxidase 4
/
Resveratrol
/
Hypoxia
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2020
Type:
Article
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