Progress of epithelial-mesenchymal transition in respiratory system and the modulatory mechanism of cell adhesion / 生理学报
Acta Physiologica Sinica
; (6): 605-616, 2020.
Article
in Zh
| WPRIM
| ID: wpr-878206
Responsible library:
WPRO
ABSTRACT
Epithelial-mesenchymal transition (EMT) plays an important role in the development and pathogenesis of respiratory system. Epithelial cells are characterized by well-developed, intercellular contacts, whereas EMT triggers the sequential destabilization of cell-cell adhesive junctions. The dynamic remodeling of the epithelial cell adhesion molecules is important for maintaining the integrity and normal function of epithelium. This paper reviews the research progress of EMT in lung development, lung injury repair and chronic lung diseases, and summarizes the effect of cell junctions and cell adhesion molecules on EMT molecular events.
Full text:
1
Index:
WPRIM
Main subject:
Respiratory System
/
Cell Adhesion Molecules
/
Cell Adhesion
/
Epithelial Cells
/
Epithelial-Mesenchymal Transition
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2020
Type:
Article