Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease / 生理学报
Acta Physiologica Sinica
;
(6): 89-102, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-878239
ABSTRACT
Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). Genetic vulnerability, aging, environmental insults are believed to contribute to the pathogenesis of PD. However, the cellular and molecular mechanism of dopaminergic neurons degeneration remains incompletely understood. Dopamine (DA) metabolism is a cardinal physiological process in dopaminergic neurons, which is closely related to the loss of dopaminergic neurons in the SN. DA metabolism takes part in several pathological processes of PD neurodegeneration, such as iron metabolism disturbance, α-synuclein mis-folding, endoplasmic reticulum stress, protein degradation dysfunction, neuroinflammatory response, etc. In this review, we will describe altered DA metabolism and its contributions to PD pathogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Substantia Nigra
/
Dopamine
/
Alpha-Synuclein
/
Dopaminergic Neurons
Type of study:
Etiology study
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2021
Type:
Article
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