Prostate organoid technology - the new POT of gold in prostate stem cell and cancer research / 生理学报
Acta Physiologica Sinica
;
(6): 181-196, 2021.
Article
in English
| WPRIM
| ID: wpr-878247
ABSTRACT
Organoids are self-organized cellular clusters in three-dimensional culture, which can be derived from a single stem cell, progenitor or cell clusters of different lineages resembling in vivo tissue architecture of an organ. In the recent years, organoids technology has contributed to the revolutionary changes in stem cell and cancer fields. In this review, we have briefly overviewed the emerging landscape of prostate organoid technology (POT) in prostate research. In addition, we have also summarized the potential application of POT in the understanding of prostate stem cell and cancer biology and the discovery of novel therapeutic strategies for prostate cancer. Lastly, we have critically discussed key challenges that lie in the current state of POT and provided a future perspective on the second-generation of POT, which should better recapitulate cellular behaviors and drug responses of prostate cancer patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Stem Cells
/
Technology
/
Organoids
/
Gold
/
Neoplasms
Limits:
Humans
/
Male
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2021
Type:
Article
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