Progress on the role of reactive oxygen species-mediated tumor microenvironment in pancreatic cancer / 生理学报
Acta Physiologica Sinica
;
(6): 197-207, 2021.
Article
in English
| WPRIM
| ID: wpr-878248
ABSTRACT
Pancreatic cancer (PC) is a devastating malignant tumor with high incidence and mortality rate worldwide. Meanwhile, the surgical approaches and drugs of this disease remain challenging. In recent years, reactive oxygen species (ROSs) study has become a hotspot in the field of PC research. ROSs may regulate tumor mic roenvironment (TME), cancer stem cells (CSCs) renewal and epithelial-mesenchymal transition (EMT), which result in drug-resistance and recurrence of the PC. Currently, TME that includes immune infiltrates, fibroblasts, vascular vessels and extracellular matrix has become a hotspot in the cancer research. Meanwhile, numerous researches have shown that ROSs-mediated TME plays a central role in the occurrence and development of PC. Targeting ROSs may be promising therapeutic treatments for the PC patients. Therefore, the purposes of the review were manifold (1) to summarize the regulations of ROSs in tumorigenesis and drug-resistance of PC; (2) to investigate the modulation of ROSs in signaling cascades in PC; (3) to study the effects of ROSs in stromal cells in PC; (4) to generalize the potent therapies targeting ROSs in PC. Overall, this review summarized the current status of ROSs in PC research and suggested some potential anti-PC drugs that may target ROSs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Neoplasms
/
Neoplastic Stem Cells
/
Reactive Oxygen Species
/
Epithelial-Mesenchymal Transition
/
Tumor Microenvironment
Limits:
Humans
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS