Assessment of Benchmark Dose in BEAS-2B Cells by Evaluating the Cell Relative Viability with Particulates in Motorcycle Exhaust / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 272-281, 2021.
Article
in English
| WPRIM
| ID: wpr-878359
ABSTRACT
Objective@#This study aimed to use an air-liquid interface (ALI) exposure system to simulate the inhalation exposure of motorcycle exhaust particulates (MEPs) and then investigate the benchmark dose (BMD) of MEPs by evaluating cell relative viability (CRV) in lung epithelial BEAS-2B cells.@*Methods@#The MEPs dose was characterized by measuring the number concentration (NC), surface area concentration (SAC), and mass concentration (MC). BEAS-2B cells were exposed to MEPs at different concentrations @*Results@#Our results reveal that BMD of NC and SAC were estimated by the best-fitting Hill model, while MC was estimated by Polynomial model. The BMDL for CRV following ALI exposure to MEPs were as follows 364.2#/cm @*Conclusion@#These results indicate that MEPs exposure
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vehicle Emissions
/
Motorcycles
/
Bronchi
/
Cell Line
/
Cell Survival
/
Benchmarking
/
Epithelial Cells
/
Particulate Matter
Limits:
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2021
Type:
Article
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