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Association between periodontal indexes and biomarkers in gingival crevicular fluid and preterm birth in pregnancy: a nested case-control study / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 58-63, 2021.
Article in English | WPRIM | ID: wpr-878410
ABSTRACT
OBJECTIVES@#This study aimed to investigate the association between periodontal indexes and biomarkers in gingival crevicular fluid (GCF) and preterm birth (PTB) in pregnancy, as well as to assess the clinical value of these indexes as predictors of PTB.@*METHODS@#A nested case-control study was conducted. A total of 300 systematically healthy pregnant women were selected within 36 weeks of gestation and grouped according to the enrolled weeks. Periodontal indexes, including probing depth (PD), bleeding index (BI), gingival index (GI), and five biomarkers in GCF, including interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), and 8-hydroxy-2-deoxyguanosine (8-OHdG) were measured at the enrolled date. The detailed birth outcome was recorded.@*RESULTS@#Only women at 24-28 weeks of gestation per PTB case (four full-term births) were selected as controls subjects, PTB displayed significantly greater GI, BI, and 8-OHdG (@*CONCLUSIONS@#Increased BI and 8-OHdG at 24-28 weeks of gestation are risk factors for PTB. Their combined detection may have some value in the prediction of PTB, but further studies with a larger sample size are needed to explore it and thus provide experiment evidence for establishing an early warning system for PTB in pregnant women with periodontal disease.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / Case-Control Studies / Periodontal Index / Gingival Crevicular Fluid / Premature Birth Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / Case-Control Studies / Periodontal Index / Gingival Crevicular Fluid / Premature Birth Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article