Mechanism, prevention, and treatment for medication-related osteonecrosis of the jaws / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 245-254, 2021.
Article
in English
| WPRIM
| ID: wpr-878439
ABSTRACT
The morbidity rate of medication-related osteonecrosis of the jaws (MRONJ) increased rapidly in recent years. Thusfar, the mechanism of MRONJ has no consensus. The possible mechanisms may include bone remodeling inhibition theory, angiogenesis inhibition theory, oral microorganism infection theory, immunosuppression theory, cytotoxicity-targeted oral epithelial cells, microcrack formation of maxillary or mandibular bone, and single nucleotide polymorphism. However, the efficacy of prevention and treatment based on a single mechanism is not ideal. Routine oral examination before MRONJ-related drug treatment, treatment of related dental diseases, and regular oral follow-up during drug treatment are of great significance for the prevention of MRONJ. During the treatment of MRONJ, the stage of MRONJ must be determined accurately, treatment must be standardized in accordance with the guidelines, and personalized adjustments must be made considering the specific conditions of patients. This review aimed to combine the latest research and guidelines for MRONJ and the experiences on the treatment of MRONJ in the Maxillofacial Surgery Department of West China Hospital of Stomatology, Sichuan University, and discuss the strategies to improve the clinical process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
China
/
Bone Remodeling
/
Bone Density Conservation Agents
/
Bisphosphonate-Associated Osteonecrosis of the Jaw
/
Jaw
Type of study:
Practice guideline
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
West China Journal of Stomatology
Year:
2021
Type:
Article
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