Research progress of Pictet-Spenglerases / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2001-2016, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-878461
ABSTRACT
Pictet-Spenglerases (P-Sases) catalyze the Pictet-Spengler (P-S) reactions and exhibit high stereoselectivity and regioselectivity under mild conditions. The typical P-S reaction refers to the condensation and recyclization of β-arylethylamine with aldehyde or ketone under acidic conditions to form tetrahydroisoquinoline and β-carboline alkaloid derivatives. The related enzymatic products of P-Sases are the backbones of various bioactive compounds, including clinical drugs morphine, noscapine, quinine, berberine, ajmaline, morphine. Furthermore, the activity of P-Sases in stereoselective and regioselective catalysis is also valuable for chemoenzymatic synthesis. Therefore, this review summarizes the research progress in the discovery, functional identification, biological characteristics and catalytic applications of P-Sases, which provide the useful theoretical reference in future P-Sases research and development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research
/
Catalysis
/
Tetrahydroisoquinolines
/
Alkaloids
/
Enzymes
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2020
Type:
Article
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