Three-dimensional chromosome conformation capture and its derived technologies / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2040-2050, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-878464
ABSTRACT
Linear chromatin is compacted into eukaryotic nucleus through a complex and multi-layered architecture. Consequently, chromatin conformation in a local or long-distance manner is strongly correlated with gene expression. Chromosome conformation capture (3C) technology, together with its variants like 4C/5C/Hi-C, has been well developed to study chromatin looping and whole genome structure. In this review, we introduce new technologies including chromosome capture combined with immunoprecipitation, nuclei acid-based hybridization, single cell and genome sequencing, as well as their application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chromatin
/
Cell Nucleus
/
Genetic Techniques
/
Chromosomes
/
Genome
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2020
Type:
Article
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