Application of glycan microarrays in cancer research / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2313-2326, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-878488
ABSTRACT
Glycosylation is one of the common post-translational modifications of proteins to regulate the ability of tumor invasion, metastasis and tumor heterogeneity by interacting with glycan-binding proteins such as lectins and antibodies. Glycan microarray can be constructed by chemical synthesis, chemical-enzyme synthesis or natural glycan releasing. Glycan microarray is an essential analytical tool to discover the interaction between glycan and its binding proteins. Here we summarize the standard techniques to construct glycan microarray for the application in cancer vaccine, monoclonal antibody and diagnostic markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polysaccharides
/
Glycosylation
/
Microarray Analysis
/
Lectins
/
Antibodies, Monoclonal
/
Neoplasms
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2020
Type:
Article
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