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Progress in human epidermal growth factor research / 生物工程学报
Chinese Journal of Biotechnology ; (12): 2813-2823, 2020.
Article in Chinese | WPRIM | ID: wpr-878531
ABSTRACT
Human epidermal growth factor (hEGF) is a typical member of the growth factor family that activates epidermal growth factor receptors. It is synthesized and secreted by multiple tissues and organs of the human body, regulating the cell proliferation, differentiation and migration via binding to receptors and activating a series of signaling pathways. In recent years, the research on hEGF has been extended to its role in human physiology and pathology, especially in tissue regeneration and wound healing. This paper reviews the research progress of hEGF, briefly describes its gene and protein structure and characteristics, mechanisms and biological effects, with the emphasis on the roles and influences in the healing of gastrointestinal ulcers, skin wound repair and tumor pathology.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Wound Healing / Cell Proliferation / Epidermal Growth Factor / ErbB Receptors Limits: Humans Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Wound Healing / Cell Proliferation / Epidermal Growth Factor / ErbB Receptors Limits: Humans Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2020 Type: Article