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Current status and future perspectives of metabolic network models of industrial microorganisms / 生物工程学报
Chinese Journal of Biotechnology ; (12): 860-873, 2021.
Article in Chinese | WPRIM | ID: wpr-878601
ABSTRACT
Genome-scale metabolic network model (GSMM) is an extremely important guiding tool in the targeted modification of industrial microbial strains, which helps researchers to quickly obtain industrial microbes with specific traits and has attracted increasing attention. Here we reviewe the development history of GSMM and summarized the construction method of GSMM. Furthermore, the development and application of GSMM in industrial microorganisms are elaborated by using four typical industrial microorganisms (Bacillus subtilis, Escherichia coli, Corynebacterium glutamicum, and Saccharomyces cerevisiae) as examples. In addition, prospects in the development trend of GSMM are proposed.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Corynebacterium glutamicum / Escherichia coli / Metabolic Networks and Pathways / Metabolic Engineering Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Corynebacterium glutamicum / Escherichia coli / Metabolic Networks and Pathways / Metabolic Engineering Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article