Pathway design and key enzyme analysis of diosgenin biosynthesis / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1178-1188, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-878623
ABSTRACT
As a naturally occurring steroid sapogenin, diosgenin acts as the precursor of hundreds of steroid medicines, and thereby has important medicinal value. Currently, industrial production of diosgenin relies primarily on chemical extraction from plant materials. Clearly, this strategy shows drawbacks of excessive reliance on plant materials and farmland as well as environment pollution. Due to development of metabolic engineering and synthetic biology, bio-production of diosgenin has garnered plenty of attention. Although the biosynthetic pathways of diosgenin have not been completely identified, in this review, we outline the identified biosynthetic pathways and key enzymes. In particular, we suggest heterologous biosynthesis of diosgenin in Saccharomyces cerevisiae. Overall, this review aims to provide valuable insights for future complete biosynthesis of diosgenin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Diosgenin
/
Biosynthetic Pathways
/
Metabolic Engineering
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS