Construction of Escherichia coli cell factories / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1564-1577, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-878655
ABSTRACT
As an important model industrial microorganism, Escherichia coli has been widely used in pharmaceutical, chemical industry and agriculture. In the past 30 years, a variety of new strategies and techniques, including artificial intelligence, gene editing, metabolic pathway assembly, and dynamic regulation have been used to design, construct, and optimize E. coli cell factories, which remarkably improved the efficiency for biotechnological production of chemicals. In this review, three key aspects for constructing E. coli cell factories, including pathway design, pathway assembly and regulation, and optimization of global cellular performance, are summarized. The technologies that have played important roles in metabolic engineering of E. coli, as well as their future applications, are discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Artificial Intelligence
/
Escherichia coli
/
Metabolic Networks and Pathways
/
Metabolic Engineering
/
Gene Editing
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2021
Type:
Article
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