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Toll-like Receptor Agonists in Radiation Protection / 中国医学科学院学报
Article in Chinese | WPRIM | ID: wpr-878681
Responsible library: WPRO
ABSTRACT
Ionizing radiation causes the massive apoptosis of human tissue cells,leading to dysfunction of the gastrointestinal tract and hematopoietic system.Thus,high-efficiency,low-toxicity radiation protection drugs are urgently needed.Toll-like receptor agonists have been developed based on the anti-apoptotic mechanism of tumor cells in recent years,which exert their radioprotective effects by activating downstream pathways,mainly nuclear factor-κB.Here we elucidate several agonists of Toll-like receptors involved in radiation protection,with an attempt to inform the research and development of new radiation protection agents.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiation, Ionizing / Radiation Protection / Radiation-Protective Agents / Humans / NF-kappa B / Apoptosis / Toll-Like Receptors Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiation, Ionizing / Radiation Protection / Radiation-Protective Agents / Humans / NF-kappa B / Apoptosis / Toll-Like Receptors Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2020 Type: Article