Toll-like Receptor Agonists in Radiation Protection / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 805-809, 2020.
Article
in Zh
| WPRIM
| ID: wpr-878681
Responsible library:
WPRO
ABSTRACT
Ionizing radiation causes the massive apoptosis of human tissue cells,leading to dysfunction of the gastrointestinal tract and hematopoietic system.Thus,high-efficiency,low-toxicity radiation protection drugs are urgently needed.Toll-like receptor agonists have been developed based on the anti-apoptotic mechanism of tumor cells in recent years,which exert their radioprotective effects by activating downstream pathways,mainly nuclear factor-κB.Here we elucidate several agonists of Toll-like receptors involved in radiation protection,with an attempt to inform the research and development of new radiation protection agents.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Radiation, Ionizing
/
Radiation Protection
/
Radiation-Protective Agents
/
NF-kappa B
/
Apoptosis
/
Toll-Like Receptors
Limits:
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2020
Type:
Article