Biotransformation and enzymatic mechanism of protoberberine alkaloids / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 5884-5889, 2020.
Article
in Zh
| WPRIM
| ID: wpr-878850
Responsible library:
WPRO
ABSTRACT
Protoberberine alkaloids belong to the quaternary ammonium isoquinoline alkaloids, and are the main active ingredients in traditional Chinese herbal medicines, like Coptis chinensis. They have been widely used to treat such diseases as gastroenteritis, intestinal infections, and conjunctivitis. Studies have shown that structural modification of the protoberberine alkaloids could produce derivative compounds with new pharmacological effects and biological activities, but the transformation mechanism is not clear yet. This article mainly summarizes the researches on the biotransformation and structure modification of protoberberine alkaloids mainly based on berberine, so as to provide background basis and new ideas for studies relating to the mechanism of protoberberine alkaloids and the pharmacological activity and application of new compounds.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Berberine
/
Berberine Alkaloids
/
Biotransformation
/
Coptis
/
Alkaloids
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2020
Type:
Article