High throughput detection and characterization of red blood cells deformability by combining optical tweezers with microfluidic technique / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 848-854, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-879212
ABSTRACT
A high throughput measurement method of human red blood cells (RBCs) deformability combined with optical tweezers technology and the microfluidic chip was proposed to accurately characterize the deformability of RBCs statistically. Firstly, the effective stretching deformation of RBCs was realized by the interaction of photo-trapping force and fluid viscous resistance. Secondly, the characteristic parameters before and after the deformation of the single cell were extracted through the image processing method to obtain the deformation index of area and circumference. Finally, statistical analysis was performed, and the average deformation index parameters (
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viscosity
/
Microfluidics
/
Erythrocyte Deformability
/
Erythrocytes
/
Optical Tweezers
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2020
Type:
Article
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