Biomechanical models and numerical studies of atherosclerotic plaque / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 948-955, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-879224
ABSTRACT
Atherosclerosis is a complex and multi-factorial pathophysiological process. Researches over the past decades have shown that the development of atherosclerotic vulnerable plaque is closely related to its components, morphology, and stress status. Biomechanical models have been developed by combining with medical imaging, biological experiments, and mechanical analysis, to study and analyze the biomechanical factors related to plaque vulnerability. Numerical simulation could quantify the dynamic changes of the microenvironment within the plaque, providing a method to represent the distribution of cellular and acellular components within the plaque microenvironment and to explore the interaction of lipid deposition, inflammation, angiogenesis, and other processes. Studying the pathological mechanism of plaque development would improve our understanding of cardiovascular disease and assist non-invasive inspection and early diagnosis of vulnerable plaques. The biomechanical models and numerical methods may serve as a theoretical support for designing and optimizing treatment strategies for vulnerable atherosclerosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biomechanical Phenomena
/
Computer Simulation
/
Atherosclerosis
/
Plaque, Atherosclerotic
/
Inflammation
/
Models, Cardiovascular
Type of study:
Prognostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2020
Type:
Article
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