Inhibition of Murine Allergic Response by Monoclonal Interleukin-4 Receptor Antibody
Journal of Rhinology
;
: 149-153, 2000.
Article
in English
| WPRIM
| ID: wpr-87954
ABSTRACT
BACKGROUND AND OBJECTIVES:
Several strategies were used to control the IgE production by interfering the functional activities of IL-4. However, most of them revealed limited effects to reduction of allergic response. This study was aimed to investigate the effects of interleukin-4 receptor (IL-4R) antibody on allergic response in animal model of allergic rhinitis. MATERIALS ANDMETHODS:
Male BALB/C mice were sensitized with intraperitoneal injection of ovalbumin (OVA). IL-4R antibody was injected intravenously before intranasal challenge of OVA with ultrasonic nebulizer. Allergic symptoms, a number of eosinophils in nasal mucosa and serum level of OVA-specific IgE were evaluated.RESULTS:
In IL-4R antibody treated mice, allergic symptom score were decreased (53.5%) than in control mice. The number of eosinophils in nasal mucosa were also reduced (47.4%). However, serum level of OVA-specific IgE were not obviously reduced (14.3%).CONCLUSION:
These results suggested that IL-4R antibody has a potential effect for the treatment of allergic rhinitis in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovum
/
Ultrasonics
/
Nebulizers and Vaporizers
/
Immunoglobulin E
/
Ovalbumin
/
Rhinitis
/
Interleukin-4
/
Models, Animal
/
Eosinophils
/
Injections, Intraperitoneal
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Journal of Rhinology
Year:
2000
Type:
Article
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