Advances in research on the development of female germ cells / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 286-289, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-879573
ABSTRACT
The development of female germ cells can be mainly divided into two stages fetal germ cells and oocytes in folliculogenesis after puberty. Mitosis-meiosis transition, meiosis arrest and re-activation are the key phases of the development. Several phases may be characterized by their distinct molecular events, which involve precise regulation of gene expression and interaction with corresponding gonadal niche cells. In recent years, single-cell transcriptome studies have clarified phase-specific patterns of gene expression, signaling pathways and epigenetic modification during oogenesis and folliculogenesis. These works have provided important insights into the development of female germ cells and pathogenesis of germ-cell related diseases, which may promote clinical application of reproductive genetic research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Oogenesis
/
Signal Transduction
/
Germ Cells
/
Meiosis
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS