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Cut-off value of white blood cell count in the diagnosis of early-onset sepsis in neonates / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1159-1163, 2020.
Article in Chinese | WPRIM | ID: wpr-879769
ABSTRACT
OBJECTIVE@#To study the clinical significance and cut-off value of white blood cell (WBC) count in the diagnosis of early-onset sepsis (EOS) in neonates.@*METHODS@#A retrospective analysis was performed on 306 neonates with EOS who were admitted from January 2019 to March 2020. A total of 580 children without infection who were admitted during the same period of time were enrolled as the control group. General status and WBC count were compared between the two groups. The diagnostic value of WBC count was analyzed based on the diagnostic and therapeutic protocol of neonatal sepsis in 2003 (referred to as the 2003 diagnostic and therapeutic protocol) and the expert consensus on the diagnosis and treatment of neonatal sepsis (2019 edition) (referred to as the 2019 expert consensus).@*RESULTS@#According to the two different diagnosis and treatment protocols, the statistical analysis showed that WBC count had a relatively positive rate (51.3% and 32.0% respectively) but a relatively high specificity (93.3% and 98.6% respectively). The receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve of WBC count in the 2003 diagnostic and therapeutic protocol was larger than that in the 2019 expert consensus (P<0.05).@*CONCLUSIONS@#The cut-off value of WBC ≥25×10
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: C-Reactive Protein / Retrospective Studies / ROC Curve / Neonatal Sepsis / Leukocyte Count Type of study: Diagnostic study / Practice guideline / Observational study / Prognostic study Limits: Humans / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: C-Reactive Protein / Retrospective Studies / ROC Curve / Neonatal Sepsis / Leukocyte Count Type of study: Diagnostic study / Practice guideline / Observational study / Prognostic study Limits: Humans / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article