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Clinical characteristics and prognostic analysis of pediatric pro-B cell acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1286-1294, 2020.
Article in Chinese | WPRIM | ID: wpr-879791
ABSTRACT
OBJECTIVE@#To explore the clinical-biological characteristics and prognosis of pediatric pro-B cell acute lymphoblastic leukemia (pro-B-ALL).@*METHODS@#A total of 64 patients aged less than 18 years old with pro-BALL were enrolled. Clinical characteristics, therapeutic effect and prognostic factors were retrospectively analyzed.@*RESULTS@#Pro-B-ALL occurred in 6.23% (64/1 028) of pediatric ALL. Among the 64 patients, 35 were male and 29 were female. The median age was 7.0 years (range 0.4-16.0 years) at diagnosis, of which 39% and 6% were ≥ 10 years old and < 1 year old respectively. The median WBC count was 25.5×10@*CONCLUSIONS@#Pediatric pro-B ALL is a heterogeneous disease with clinical and biological diversity. Biological characteristics, such as immunological markers, genetic alterations, and MRD at 3 months after chemotherapy may be important factors for the long-term prognosis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Antigens, CD / Retrospective Studies / Histone-Lysine N-Methyltransferase / Neoplasm, Residual / Disease-Free Survival / Myeloid-Lymphoid Leukemia Protein Type of study: Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Antigens, CD / Retrospective Studies / Histone-Lysine N-Methyltransferase / Neoplasm, Residual / Disease-Free Survival / Myeloid-Lymphoid Leukemia Protein Type of study: Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2020 Type: Article