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Clinical effect and mechanism of total glucosides of paeony in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis: a prospective randomized controlled study / 中国当代儿科杂志
Article in Chinese | WPRIM | ID: wpr-879808
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To study the clinical effect and mechanism of total glucosides of paeony (TGP) in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis (HSPN).@*METHODS@#Sixty-four HSPN children with moderate proteinuria were divided into a TGP treatment group (@*RESULTS@#Compared with the healthy children before treatment, the children with HSPN had higher proportion of Tfh cells and expression levels of IL-21 and IL-4 (@*CONCLUSIONS@#TGP has a marked clinical effect in the treatment of HSPN and can reduce the inflammatory response of the kidney and exert a protective effect on the kidney by inhibiting the proliferation of Tfh cells and downregulating the expression of IL-21 and IL-4 in plasma.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Purpura, Schoenlein-Henoch / Humans / Child / Prospective Studies / Paeonia / Glucosides / Nephritis Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Purpura, Schoenlein-Henoch / Humans / Child / Prospective Studies / Paeonia / Glucosides / Nephritis Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article