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Epidemiological characteristics of respiratory syncytial virus in hospitalized children with acute lower respiratory tract infection in Chongqing, China, from 2013 to 2018: an analysis of 2 066 cases / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 67-73, 2021.
Article in Chinese | WPRIM | ID: wpr-879811
ABSTRACT
OBJECTIVE@#To study the detection rate, epidemic pattern, and clinical features of respiratory syncytial virus (RSV) in hospitalized children with acute lower respiratory infection (ALRI).@*METHODS@#Nasopharyngeal aspirates were collected from children with ALRI, aged < 2 years, who were hospitalized in Children's Hospital of Chongqing Medical University from June 2013 to May 2018. Multiplex PCR was used to detect 16 common respiratory viruses. The epidemiological characteristics of RSV were analyzed.@*RESULTS@#A total of 2 066 hospitalized children with ALRI were enrolled. Among the children, 1 595 (77.20%) tested positive for virus and 826 (39.98%) tested positive for RSV [410(49.6%) positive for RSV-A, 414 (50.1%) positive for RSV-B, and 2 (0.2%) positive for both RSV-A and RSV-B]. RSV-B was the main subtype detected in 2013-2014 and 2016-2017, while RSV-A was the main subtype in 2014-2015 and 2017-2018, and these two subtypes were prevalent in 2015-2016. The highest detection rate of RSV was noted in winter. RSV + human rhinovirus was the most common combination of viruses and was detected in 123 children. These children were more likely to develop wheezing than those with single RSV detected (@*CONCLUSIONS@#In Chongqing in 2013-2018, RSV-A and RSV-B not only can predominate alternately, but also can co-circulate during a season. RSV is the major viral pathogen of hospitalized children with ALRI and can cause severe lower respiratory tract infection. There are no differences in clinical manifestations between children with RSV-A infection and those with RSV-B infection, but boys are more susceptible to RSV-A infection.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Respiratory Tract Infections / Child, Hospitalized / China / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Respiratory Tract Infections / Child, Hospitalized / China / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections Limits: Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article