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Efficacy and safety of mycophenolate mofetil versus cyclophosphamide in the treatment of Henoch-Schönlein purpura nephritis with nephrotic-range proteinuria in children: a prospective randomized controlled trial / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 338-342, 2021.
Article in Chinese | WPRIM | ID: wpr-879857
ABSTRACT
OBJECTIVE@#To study the efficacy and safety of mycophenolate mofetil (MMF) versus cyclophosphamide (CTX) in the treatment of children with Henoch-Schönlein purpura nephritis (HSPN) and nephrotic-range proteinuria.@*METHODS@#A prospective clinical trial was conducted in 68 pediatric patients who were admitted to the Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics and who were diagnosed with HSPN and nephrotic-range proteinuria from August 2016 to November 2019. The patients were randomly divided into two groupsMMF treatment (@*RESULTS@#At months 3, 6, and 12 of treatment, there was no significant difference in the complete remission rate and the response rate between the MMF treament and CTX treatment groups (@*CONCLUSIONS@#MMF and CTX have similar efficacy and safety in the treatment of HSPN children with nephrotic-range proteinuria.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Proteinuria / IgA Vasculitis / Prospective Studies / Retrospective Studies / Cyclophosphamide / Immunosuppressive Agents / Mycophenolic Acid / Nephritis Type of study: Observational study Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Proteinuria / IgA Vasculitis / Prospective Studies / Retrospective Studies / Cyclophosphamide / Immunosuppressive Agents / Mycophenolic Acid / Nephritis Type of study: Observational study Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2021 Type: Article