Effects of delivery and storage conditions on concentrations of amino acids and carnitines in neonatal dried blood spots / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 565-573, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-879913
ABSTRACT
OBJECTIVE@#To explore effects of different delivery and storage conditions on concentrations of amino acids and carnitines in neonatal dried blood spots (DBS), so as to provide evidence for improving accurate and reliable detection by tandem mass spectrometry.@*METHODS@#A total of 1 254 616 newborn DBS samples in Newborn Screening Center of Zhejiang Province were delivered and stored at room temperature (group A, @*RESULTS@#The concentrations of amino acids and carnitines in the three groups were skewed, and the differences in amino acid and carnitine concentrations among groups were statistically significant (all @*CONCLUSIONS@#Cold-chain logistics system and storage in low temperature and low humidity can effectively reduce degradation of some amino acids and carnitines in DBS, improve the accuracy and reliability of detection, and thus ensures the quality of screening for neonatal metabolic diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Specimen Handling
/
Temperature
/
Time Factors
/
Carnitine
/
Reproducibility of Results
/
Neonatal Screening
/
Tandem Mass Spectrometry
/
Dried Blood Spot Testing
/
Amino Acids
/
Humidity
Limits:
Humans
/
Infant, Newborn
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2020
Type:
Article
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