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Research progress on the role of pentraxin 3 in polycystic ovary syndrome / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 637-643, 2020.
Article in Chinese | WPRIM | ID: wpr-879925
ABSTRACT
Polycystic ovary syndrome (PCOS) is a common endocrine disease of child-bearing period women and one of the main causes of infertility in women. Pentraxin 3 (PTX3) is a multifunctional protein with a series of biological activities. PTX3 participates in the regulation of insulin secretion and glucose metabolism, ovarian cumulus cell function, inflammatory factor activity, androgen metabolism, lipid absorption and transport, and endothelial cell function, thereby improving insulin resistance, promoting follicular development and ovulation, reducing chronic inflammation, inhibiting androgen levels, improving lipid metabolism abnormalities and preventing atherosclerosis and cardiovascular diseases, thus participating in the occurrence of PCOS and its complications. This article reviews the mechanism of PTX3 in PCOS and its complications, trying to provide new ideas and directions for the study of PCOS pathogenesis and its clinical diagnosis and treatment.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polycystic Ovary Syndrome / C-Reactive Protein / Insulin Resistance / Serum Amyloid P-Component Limits: Child / Female / Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polycystic Ovary Syndrome / C-Reactive Protein / Insulin Resistance / Serum Amyloid P-Component Limits: Child / Female / Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2020 Type: Article