Protective effect of iridoid glycosides of radix scrophulariae on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 705-713, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-879932
ABSTRACT
OBJECTIVE@#To investigate the regulatory effect of iridoid glycoside of radix scrophulariae (IGRS) on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion @*METHODS@#Rat pheochromocytoma PC12 cells were pretreated with IGRS (50, 100, 200 μg/mL) for 24h, and the @*RESULTS@#The damage caused by OGD/R to PC12 cells was significantly reduced by IGRS, with significant effect on increasing survival rate and reducing LDH release (all @*CONCLUSIONS@#IGRS has neuroprotective effect, which may alleviate cerebral ischemia-reperfusion injury by regulating SERCA2, maintaining calcium balance, and inhibiting endoplasmic reticulum stress-mediated apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Snails
/
In Vitro Techniques
/
Reperfusion
/
Reperfusion Injury
/
Down-Regulation
/
Cell Survival
/
PC12 Cells
/
Iridoid Glycosides
/
Endoplasmic Reticulum Stress
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2020
Type:
Article
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