Interaction between RAS gene and lipid metabolism in cancer / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 17-22, 2021.
Article
in English
| WPRIM
| ID: wpr-879949
ABSTRACT
The gene is frequently mutated and abnormally activated in many cancers,and plays an important role in cancer development. Metabolic reprogramming occurs in malignant tumors,which can be one of the key targets for anti-tumor therapy. gene can regulate lipid metabolism through AKT-mTORC1 single axis or multiple pathways,such as lipid synthesis pathways and degradation pathways. Similarly,lipid metabolism can also modify and activate RAS protein and its downstream signaling pathways. This article overviews the current research progress on the interaction between lipid metabolism and ,to provide insight in therapeutic strategies of lipid metabolism for -driven tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Genes, ras
/
Ras Proteins
/
Lipid Metabolism
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2021
Type:
Article
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