Advances on molecular mechanism of hepatitis B virus-induced hepatocellular carcinoma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 113-122, 2021.
Article
in En
| WPRIM
| ID: wpr-879952
Responsible library:
WPRO
ABSTRACT
The pathogenesis of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is complicated with the crosstalk of multiple factors and the multi-step processes. The main mechanisms underlying the HBV-induced HCC include:①integration of HBV DNA into the host hepatocyte genome to alter gene function at the insertion site,resulting in host genome instability and expression of carcinogenic truncated proteins;②HBV gene mutations at S,C,and X coding regions in the genome;③HBV X gene-encoded HBx protein activates proto-oncogenes and inhibits tumor suppressor genes,leading to the HCC occurrence. In this article,the recent research progress on the molecular mechanism of HBV-induced HCC is comprehensively reviewed,so as to provide insights into the prevention,early prediction and postoperative adjuvant therapy of HCC.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Hepatitis B virus
/
Carcinoma, Hepatocellular
/
Hepatocytes
/
Hepatitis B
/
Liver Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2021
Type:
Article