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Postoperative serum triglyceride levels in predicting risk of new-onset diabetes mellitus in patients following liver transplantation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 239-244, 2021.
Article in English | WPRIM | ID: wpr-879966
ABSTRACT
To investigate the postoperative serum triglyceride (TG) levels in predicting the risk of new-onset diabetes mellitus (NODM) in patients following allogeneic liver transplantation. One hundred and forty three patients undergoing allogeneic liver transplantation in Shanghai General Hospital from July 2007 to July 2014 were enrolled in this study. The NODM developed in 33 patients after liver transplantation. The curve of dynamic TG levels in the early period after liver transplantation was generated. Independent risk factors of NODM were determined by univariate and multivariant logistic regression analyses. The clinical value of TG in predicting NODM was analyzed by area under the ROC curve (AUC). Serum TG levels were gradually rising in the first week and then reached the plateau phase (stable TG, sTG) in patients after surgery. The sTG in NODM group were significantly higher than that in non-NODM group (=-2.31, <0.05). Glucocorticoid therapy (=4.054, <0.01), FK506 drug concentration in the first week after operation (=3.482, <0.05) and sTG (=3.156, <0.05) were independent risk factors of NODM. ROC curve analysis showed that the AUC of sTG in predicting NODM was 0.72. TG shows a gradual recovery process in the early period after liver transplantation, and the higher TG level in stable phase may significantly increase the risk of NODM in patients.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Triglycerides / China / Risk Factors / Liver Transplantation / Tacrolimus / Diabetes Mellitus Type of study: Etiology study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Journal of Zhejiang University. Medical sciences Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Triglycerides / China / Risk Factors / Liver Transplantation / Tacrolimus / Diabetes Mellitus Type of study: Etiology study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Journal of Zhejiang University. Medical sciences Year: 2021 Type: Article