Research Progress of Expression and Clinical Significant of EZH2 in Hematological Malignancies--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 2097-2012, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-880022
ABSTRACT
Enhancer of zeste homolog 2(EZH2) is a histone methyltransferase which regulate gene expression through epigenetic machinery. The abnormal expression of EZH2 has been described in many cancer types. With in-depth study, it was found that EZH2 is involved in the occurrence and development in many kinds of malignant hematologic disease which may play a dual role of oncogenes and tumor suppressor genes. In recent years, the emergence of EZH2 inhibitors provide a new option for the future treatment of hematological malignancies. In this review, the expression and clinical significance of EZH2 in various of hematological tumors were summarized briefly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Research
/
Hematologic Neoplasms
/
Enhancer of Zeste Homolog 2 Protein
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2020
Type:
Article
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