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Analysis of the Different Therapeutic Effects in 21 Ph / 中国实验血液学杂志
Article in Chinese | WPRIM | ID: wpr-880028
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To analyze the outcomes of the children suffered from philadelphia chromosome positive acute lymphoblastic leukemia (Ph@*METHODS@#21 cases of firstly diagnosed Ph@*RESULTS@#Among 21 patients, 17 were male and 4 were female with a median age of 8 years old (range, 4-12 years), the median follow-up time was 30 moths (range, 10-133 months). All the patients were treated with chemotherapy induced by the high-risk project of CCLG-ALL 2008. Among 14 patients treated with TKI plus chemotherapy, nine patients achieved complete remission. During 3 months after treatment, patients without complete molecular response or with the second complete remission and intensity desire of transplantation were treated with allo-HSCT, among 9 patients with allo-HSCT, six patients achieved long term survival.@*CONCLUSION@#At TKI era, TKI combined with strong chemotherapy can make Ph
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Philadelphia Chromosome / Aged / Female / Humans / Male / Child / Retrospective Studies / Hematopoietic Stem Cell Transplantation / Protein Kinase Inhibitors / Precursor Cell Lymphoblastic Leukemia-Lymphoma Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Philadelphia Chromosome / Aged / Female / Humans / Male / Child / Retrospective Studies / Hematopoietic Stem Cell Transplantation / Protein Kinase Inhibitors / Precursor Cell Lymphoblastic Leukemia-Lymphoma Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article