Costunolide Induces Apoptosis of K562/ADR Cells through PI3K/AKT Pathway / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 68-71, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-880033
ABSTRACT
OBJECTIVE@#To explore the effects of costunolide on the proliferation and apoptosis of human chronic myeloid leukemia drug resisitant cell line K562/ADR and its mechanism.@*METHODS@#The proliferation of the cells was assessed by CCK-8 assay, while flow cytometry was used to detect the apoptosis of the cells. The related-proteins were detected by using Western blot.@*RESULTS@#The proliferation of K526/ADR cells was significantly inhibited by costunolide in a dose-dependent manner (r=0.9886) after treated by 0.01, 0.1, 0.25, 0.5, 1, 2.5, 5, 10, 25, 50 and 100 μmol/L costunolide for 72 h, and IC@*CONCLUSION@#Costunolide could inhibit the proliferation and apoptosis of K562/ADR cells through regulation of PI3K/AKT pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sesquiterpenes
/
Apoptosis
/
Phosphatidylinositol 3-Kinases
/
K562 Cells
/
Cell Proliferation
/
Proto-Oncogene Proteins c-akt
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2021
Type:
Article
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