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Research Advance of on the Support Effect of Adipose Tissue-Derived Stem Cell on Hematopoietic Stem/Progenitor Cell--Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 301-305, 2021.
Article in Chinese | WPRIM | ID: wpr-880072
ABSTRACT
The normal hematopoiesis of the body are depends on the proliferation and differentiation of hematopoietic stem/progenitor cell (HSPC), as well as the mesenchymal stem/stromal cell (MSC) that support the growth and development of hematopoietic microenvironment of bone marrow (BM). At present, the commonly used MSC for promoting hematopoiesis are mainly derived from BM, however, the acquisition of MSC from BM is limited by the number, sampling, isolation and purification. Compared with BM, adipose tissue has many advantages, including widely distributed, abundant in source, simple and easy to obtain, and contains more pluripotent stem cell, such as adipose tissue-derived stem cell (ADSC), in which Perivascular cell/pericyte (PC) are considered as the precursor cell of MSC, also is the main components of vascular microenvironment, and plays an important role in the proliferation and differentiation of HSPC. PC is especially abundant in adipose tissue, and with the advantages of easy acquisition, small damage, fast cell proliferation and low immunogenicity. Therefore, the sustaining hematopoiess of human adipose derived-perivascular stem cell (AD-PC) to HSPC requires further research and exploration. In this review, the possible supporting effects and PC subgroup of ADSC as stromal cell on HSPC are summarized briefly.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Marrow Cells / Hematopoietic Stem Cells / Cell Differentiation / Cells, Cultured / Adipose Tissue / Hematopoietic Stem Cell Transplantation / Cell Proliferation / Mesenchymal Stem Cells Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Marrow Cells / Hematopoietic Stem Cells / Cell Differentiation / Cells, Cultured / Adipose Tissue / Hematopoietic Stem Cell Transplantation / Cell Proliferation / Mesenchymal Stem Cells Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article