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CLAG Regimen Composed of Continuous Intravenous Infusion of Cladribine in the Treatment of Refractory/Relapsed Acute Myeloid Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 333-338, 2021.
Article in Chinese | WPRIM | ID: wpr-880078
ABSTRACT
OBJECTIVE@#To study the efficacy and safety of continuous intravenous infusion of 2-Chlorodeoxyadenosine (2-CdA) combined with high-dose cytarabine (Ara-C) and granulocyte colony-stimulating factor (G-CSF) (CLAG regiem) in the treatment of relapsed/refractory acute myeloid leukemia (AML).@*METHODS@#Fifteen patients with refractory/relapsed AML hospitalized in 5 medical units such as Department of Hematology, the Affiliated Tumor Hospital of Zhengzhou University and received one course of CLAG regimen from June 2014 to August 2019 were analyzed retrospectively (specifically cladribine 5 mg/M@*RESULTS@#Among the 15 patients with refractory/relapsed AML, 9 males and 6 females, the median age was 35 (13-63) years old. FAB classification 1 case of M@*CONCLUSION@#The CLAG regimen consisting of continuous intravenous infusion of cladribine shows high CR in the treatment of AML patients, but the duration of CR is short, myelosuppression is sever, so that infection control is the key. Allogeneic hematopoietic stem cells transplantation should be performed as soon as possible after CR.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Infusions, Intravenous / Leukemia, Myeloid, Acute / Antineoplastic Combined Chemotherapy Protocols / Retrospective Studies / Granulocyte Colony-Stimulating Factor / Treatment Outcome / Cladribine / Cytarabine Type of study: Observational study Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Infusions, Intravenous / Leukemia, Myeloid, Acute / Antineoplastic Combined Chemotherapy Protocols / Retrospective Studies / Granulocyte Colony-Stimulating Factor / Treatment Outcome / Cladribine / Cytarabine Type of study: Observational study Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article