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Analysis of Clinical Characteristics and Prognosis in Children with Acute Megakaryoblastic Leukemia without Down Syndrome / 中国实验血液学杂志
Article in Chinese | WPRIM | ID: wpr-880084
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To analyze the clinical characteristics and treatment effects of children with acute megakaryoblastic leukemia without down syndrome (non-DS-AMKL).@*METHODS@#The clinical data of 19 children with non-DS-AMKL treated in the Pediatric Hematology Ward in Sun Yat-sen Memorial Hospital of Sun Yat-sen University from May 2008 to April 2018 were analyzed retrospectively. The clinical characteristics, laboratory test and treatment methods of the children were concluded. All patients were followed up to evaluate the effect of treatment.@*RESULTS@#The 19 cases of children included nine male and ten female, the median age of onset was 2 years old. The clinical manifestations showed nonspecific. The median white blood cell of peripheral blood was 15.88×10@*CONCLUSION@#Non-DS-AMKL was rare in children and difficult to be diagnosed. Determination of MICM classification as early as possible was helpful for diagnosis, and genetic testing played an important role for diagnosis and prognosis evaluation. Early hematopoietic stem cell transplantation in patients with CR after chemotherapy might be an effective way to cure AMKL.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Trisomy / Female / Humans / Male / Leukemia, Megakaryoblastic, Acute / Child / Child, Preschool / Retrospective Studies / Down Syndrome Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Trisomy / Female / Humans / Male / Leukemia, Megakaryoblastic, Acute / Child / Child, Preschool / Retrospective Studies / Down Syndrome Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article