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The Genome-Wide Changes in Expression Profile of CML T Cells After Up-regulation of TCRζ Chain Expression / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 669-676, 2021.
Article in Chinese | WPRIM | ID: wpr-880131
ABSTRACT
OBJECTIVE@#To analyze the changes in the gene expression profile of T cells in CML patients after TCRζ up-regulation expression, and to explore the molecular mechanism of T cell reactivation after transgenic up-regulation of TCRζ.@*METHODS@#The peripheral blood mononuclear cells(PBMCs) from 3 newly untreated chronic-stage CML patients were collected, and the CD3@*RESULTS@#A total of 2248 differentially-expressed genes were obtained, including 553 up-regulated genes and 1695 down-regulated genes in experimental group as compared with those in control group (P<0.05) . The GO and KEGG enrichment analyses showed that differentially expressed genes involved in the biological processes related to T cell immune function, such as TCR signaling pathway, T cell proliferation and activation. Some of core genes involved in promoting the TCR signaling pathway, T cell proliferation, activation and apoptosis pathways were significantly up-regulated, while some core genes involved in inhibiting T cell activation were significantly down-regulated.@*CONCLUSION@#The molecular mechanism of the significantly improved T cell activation and proliferation ability in CML patients after TCRζ up-regulation may be related to the differential transcripts mediated signaling pathways of T cell activation, proliferation and apoptosis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukocytes, Mononuclear / Lymphocyte Activation / Receptors, Antigen, T-Cell / T-Lymphocytes / Up-Regulation Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukocytes, Mononuclear / Lymphocyte Activation / Receptors, Antigen, T-Cell / T-Lymphocytes / Up-Regulation Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2021 Type: Article