The Role of Zyxin in Regulating Platelet Cytoskeleton Distribution / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 876-880, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-880162
ABSTRACT
OBJECTIVE@#To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton.@*METHODS@#Platelets were isolated from zyxin-knockout (Zyx@*RESULTS@#After zyxin gene was knockout, the expressions of cytoskeleton proteins β-actin, α-actinin, filamin A, and myosin Ⅱ A in resting and Jas-induced platelets were significantly increased. In the platelet spreading on fibrinogen surface, F-actin was increased in Zyx@*CONCLUSION@#Zyxin significantly regulates the distribution of platelet cytoskeleton, which plays an important role in maintaining platelet cytoskeleton homeostasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Platelets
/
Cytoskeleton
/
Actinin
/
Actins
/
Zyxin
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2021
Type:
Article
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