Research Advance of Autophagy in Acute Intestinal Graft-Versus-Host Disease--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 998-1001, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-880182
ABSTRACT
Acute intestinal graft-versus-host disease is a refractory disease which can affect implantation and become a threat to life in severe cases. Autophagy is an intracellular degradation pathway necessary for maintaining cellular energy homeostasis. In recent years, a large number of studies have found that it is closely related to the pathogenesis and process of acute intestinal graft-versus-host disease. The main mechanisms may involve that inflammatory factor storm after pretreatment and infusion of donor cells induces disordered intestinal immune tolerance, and abnormal oxidative stress damages intestinal mucosal barrier, leading to intestinal rejection of acute graft-versus-host disease via mTOR signal pathway of autophagy, disordered mitophagy and other related pathways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Signal Transduction
/
Oxidative Stress
/
Graft vs Host Disease
/
Immune Tolerance
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2021
Type:
Article
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