Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients
Kidney Research and Clinical Practice
;
: 20-27, 2015.
Article
in English
| WPRIM
| ID: wpr-88023
ABSTRACT
BACKGROUND:
Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There is controversy over the optimal hemoglobin (Hb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) patients in Korea.METHODS:
This study was a multicenter prospective observational study of maintenance HD patients that was performed for 5 years in western Seoul, Korea. Three hundred and sixty-two participants were enrolled. Laboratory values and mortality were accessed every 6 months. Repeated measures of laboratory values in each interval were averaged to obtain one semiannual mean value. The Hb values were divided into six groups (1) Hb or =13 g/dL. We analyzed the odds ratio for all-cause mortality, based on the Hb group, and adjusted for demographics and various laboratory values. Statistics were performed with SAS, version 9.1 software (SAS Institute Inc., Cary, NC, USA).RESULTS:
Mortality odds ratios relative to the reference group (10-11 g/dL) in the fully adjusted model were 3.61 for or =13 g/dL (* indicates P<0.05).CONCLUSION:
In this study, a Hb level of 10-11 g/dL was associated with the lowest mortality among the groups with Hb level<13 g/dL. Larger interventional trials are warranted to determine the optimal Hb target for Korean HD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Odds Ratio
/
Demography
/
Prospective Studies
/
Risk Factors
/
Cohort Studies
/
Mortality
/
Renal Dialysis
/
Renal Insufficiency, Chronic
/
Observational Study
/
Seoul
Type of study:
Controlled clinical trial
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2015
Type:
Article
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